Mother 3
Mother 3 was originally gonna be a N64DD game.
The original creator, Shigesato itoi, originally wanted it to be a Nintendo 64 disk-drive title, and kept working on it and pushing the release date, but because of the massive flop that was the DD, eventually Shigeru Miyamoto convinced him to release it on the GameBoy Advance. The 64 game was about 60% complete when it was abandoned.

For more information on why it was changed to be on GBA, I suggest reading this article: https://tcrf.net/Prerelease:Mother_3#N64_Version
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